Monitoring adenoviral p53 transduction efficiency by yeast functional assay
نویسندگان
چکیده
منابع مشابه
Reduced transduction efficiency of adenoviral vectors expressing human p53 gene by repeated transduction into glioma cells in vitro.
PURPOSE Recombinant adenoviral vectors are widely used in clinical and experimental studies to treat malignant tumors. Recently, host immune responses have been proposed as a major limitation in using adenoviral vectors for repeated gene delivery. We demonstrate another limitation unrelated to host immunity. EXPERIMENTAL DESIGN We repeatedly transduced an adenoviral vector expressing the huma...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 1998
ISSN: 0969-7128,1476-5462
DOI: 10.1038/sj.gt.3300605